For followers of Wicca, Lilith tends to be seen as one of many names for the Goddess, the supreme feminine divine power. So much so that Sam believed only his powers were strong enough to kill her. She then leaves, leaving the Winchesters alive due to Chuck ordering her not to kill them. Later, Ruby tells Sam that not even Lilith could resurrect a human in Hell.
Lilith is mentioned by Dean when he admits that, although he still doesn't approve of Sam having drank demon blood to do it, he is glad that Sam managed to kill her and he knows that Sam hadn't known at the time that her death was the last seal. Also, like Christ, Lilith sacrifices herself with the intention of "saving" her kind by letting Sam Winchester kill her, in a manner that resembles crucifixion. This blood moved on its own to form a symbol on the convent floor, from which Lucifer rose from the Cage. At the motel room, Dean admits he lied and Lilith begins inflicting wounds on him, threatening to cause a death by a thousand cuts. [2] He acquired the Colt and manipulated Jake Talley into using it to open a devil's gate in May 2007. When infected with ghost sickness, Dean has a hallucination of Lilith in the form of the Fremont girl, who is happy to see him, having "missed" him. [2], Even though Lilith was finally killed by Sam, her legacy endures long after her death. Though Lilith never actually used it, it was enough for the demons to know that she had it and could use it. She is the first demon to ever be created, her soul having been twisted by Lucifer as an act of spite against God that got him expelled from Heaven. Lorsque Dean se rend compte que quoi qu'il fasse, les prédictions de Chuck sont toujours justes et précises, il emmène Chuck avec lui dans le Red Motel et tente de l'utiliser pour affronter Lilith étant donné que Chuck est protégé par les Archanges, Dean a la brillante idée de faire en sorte que Chuck soit en contact direct avec Lilith pour réveiller la colère de l'archange, ce qui arriva bien sûr mais ne voulant pas subir la colère des Célestes, Lilith abandonne le corps de la femme qu'elle possédait et s'enfuit à nouveau. Se rendant compte que le démon auquel Ruby a fait allusion pendant l'assaut, Henriksen est effrayé mais en même temps très surpris mais avant que quiconque eut le temps de faire quoi que ce soit, Lilith projette son rayon brûlant détruisant tout le commissariat et tuant tous ses occupants y compris Henriksen. Elle est à l'origine un démon mésopotamien. Dean later hallucinated her as the latter in "Yellow Fever".
Sam entreats Ruby to teach him to use his powers to kill Lilith and save Dean, but she tells him that it's too late to do that now. Lilith reminds Michael that they worked together to release Lucifer and bring about the Apocalypse, while also revealing God came back on his own but Michael continues to refuse. She also revealed that Lilith has a "personal chef" who kidnaps babies for her to eat and is currently possessing Cindy McClellan.